In vivo study of wound healing processes in Sprague-Dawley model using human mesenchymal stem cells and platelet-rich plasma

Introduction: Mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) have a potential role in improving wound healing processes. This experimental study aims to compare PRP MSCs promote the process animal burn model.
 Methods: from venous blood lipoaspirates were isolated six donors. Saline solution was used as control while treatment groups injected second-degree wounds backs of 10 male Sprague-Dawley rats for each group. On day 7, 5 group euthanized analyses VEGF gene, which has angiogenesis. At end (week 5), remaining histological analysis.
 Results: The expression higher than (not significant). rate also significantly faster until 21 days post-burn getting slowly afterward. Histological analysis showed burned skin at 35 had displayed best differentiation outcome In conclusion, human-derived do not accelerate epithelialization duration model. However, they improved wound’s vascularization cell differentiation.
 Conclusion: are superior enhancing differentiation.